a Record control number 000325766500004

a ISSN 0277-0903

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number WD300

b Item number .R57 2013

a Personal name Aydoğan, Metin,

d Dates associated with a name 1945-

a Title Risk factors for persistence of asthma in children: 10-year follow-up.

h Medium Electronic Document

c Statement of responsibility, etc Metin Aydogan MD, Ahmet Ozen MD, Tunc Akkoc PhD, Aarif O Eifan MD, Esin Aktas PhD, Gunnur Deniz PhD, Izlem Gocmen MD , Nerin N. Bahceciler MD & Isil Barlan MD.

c Date of publication, distribution, etc 2013.

b Name of publisher, distributor, etc Informa Healthcare

a Place of publication, distribution, etc New York :

a Summary, etc Objective: Risk factors related to the outcome of childhood asthma are not yet well established. We aimed to investigate the long-term outcome for children with asthma to determine the risk factors in predicting persistence of disease. Methods: Sixty-two children with asthma were evaluated retrospectively at the end of a 10-year follow-up. Patients were asked to complete a questionnaire requesting clinical information, and underwent physical examination, skin prick testing, a pulmonary function test and bronchial provocation testing. Immunologic parameters evaluated were allergen-specific IgE and IgG4 levels, and allergen-induced generation of CD4(+)CD25(+) cells. Results: Mean age at final assessment was 15.9 +/- 3.6 years, and duration of follow-up was 10.30 +/- 1.27 years. Fifty percent of patients outgrew their asthma during the 10-year follow-up period. All the non-atopic patients outgrew their disease during the study period, whereas 67% of atopic patients did not. We identified two risk factors independently related to the persistence of symptoms: presence of bronchial hyper-responsiveness and presence of rhinitis. Atopic children who were in remission demonstrated significantly higher allergen-induced CD4(+)CD25(+) T cells compared to healthy controls. Conclusions: Atopy, presence of rhinitis, positive and presence of bronchial hyper-reactivity are important risk factors for the persistence of asthma in children. Allergen-induced CD4(+)CD25(+) T cells were higher in the atopic children who outgrew their disease, implicating an immunological mechanism of asthma remission in children.

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Topical term or geographic name as entry element Allergy

a Topical term or geographic name as entry element Allergic rhinitis

a Topical term or geographic name as entry element Asthma

a Topical term or geographic name as entry element Bronchial hyper-reactivity

a Topical term or geographic name as entry element Childhood

g Relationship information NOV 2013, Vol.50, Issue 9, p938-944

a Main entry heading Journal Of Asthma

x International Standard Serial Number 02770903

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.3109/02770903.2013.831872